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feat: add SEED gene-selection pipeline for cancer prognosis target ge… - #67

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ShixiangWang merged 1 commit into
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feat/seed-pipeline
Jul 31, 2026
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feat: add SEED gene-selection pipeline for cancer prognosis target ge…#67
ShixiangWang merged 1 commit into
mainfrom
feat/seed-pipeline

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…nes (#57)

Implement the SEED method (Yang et al., Cancer Letters 2025) as a four-step pipeline integrated into bregr:

  • br_seed_screen(): Univariate screening (Cox/logistic/Spearman) per gene across multiple clinical indicators, with p-value intersection
  • br_seed_select(): Lasso (glmnet) -> multivariate -> stepwise gene selection
  • br_seed_model(): Risk score model construction with coefficient extraction
  • br_seed(): All-in-one orchestrator with optional enrichment step

All functions reuse existing br_pipeline() engine for batch regression, support mirai parallelization, and return S3 list objects with cli print methods. Adds glmnet and clusterProfiler to Suggests.

…nes (#57)

Implement the SEED method (Yang et al., Cancer Letters 2025) as a four-step
pipeline integrated into bregr:

- br_seed_screen(): Univariate screening (Cox/logistic/Spearman) per gene
  across multiple clinical indicators, with p-value intersection
- br_seed_select(): Lasso (glmnet) -> multivariate -> stepwise gene selection
- br_seed_model(): Risk score model construction with coefficient extraction
- br_seed(): All-in-one orchestrator with optional enrichment step

All functions reuse existing br_pipeline() engine for batch regression,
support mirai parallelization, and return S3 list objects with cli
print methods. Adds glmnet and clusterProfiler to Suggests.

Co-Authored-By: Claude <noreply@anthropic.com>
@ShixiangWang
ShixiangWang merged commit 6100d14 into main Jul 31, 2026
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@ShixiangWang
ShixiangWang deleted the feat/seed-pipeline branch July 31, 2026 04:13
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