diff --git a/private/cc_config.bzl b/private/cc_config.bzl
index b2ce1ee1..0833eb3c 100644
--- a/private/cc_config.bzl
+++ b/private/cc_config.bzl
@@ -50,12 +50,6 @@ COPTS = select({
 }) + select({
     Label("@rules_cc//cc/compiler:clang"): [
         "-Wno-nullability-extension",
-        # Work around https://github.com/llvm/llvm-project/issues/121984 and
-        # https://github.com/bazelbuild/rules_cc/issues/729.
-        "--system-header-prefix=absl/",
-        "--system-header-prefix=google/",
-        "--system-header-prefix=tools/",
-        "--system-header-prefix=upb/",
     ],
     Label("//conditions:default"): [],
 }) + select({