diff --git a/change/react-native-windows-7a98fbf7-0186-4130-b6ab-409caa188bee.json b/change/react-native-windows-7a98fbf7-0186-4130-b6ab-409caa188bee.json
new file mode 100644
index 00000000000..b86d2e83c9b
--- /dev/null
+++ b/change/react-native-windows-7a98fbf7-0186-4130-b6ab-409caa188bee.json
@@ -0,0 +1,7 @@
+{
+  "type": "prerelease",
+  "comment": "Fix crash attempting to get runtime when shutting down instance",
+  "packageName": "react-native-windows",
+  "email": "30809111+acoates-ms@users.noreply.github.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Microsoft.ReactNative.Cxx/NativeModules.h b/vnext/Microsoft.ReactNative.Cxx/NativeModules.h
index e9afcef5b23..a0314573c63 100644
--- a/vnext/Microsoft.ReactNative.Cxx/NativeModules.h
+++ b/vnext/Microsoft.ReactNative.Cxx/NativeModules.h
@@ -527,7 +527,8 @@ struct ModuleJsiInitMethodInfo<void (TModule::*)(ReactContext const &, facebook:
     return
         [module = static_cast<ModuleType *>(module), method](
             ReactContext const &reactContext, winrt::Windows::Foundation::IInspectable const &runtimeHandle) noexcept {
-          (module->*method)(reactContext, GetOrCreateContextRuntime(reactContext, runtimeHandle));
+          if (runtimeHandle)
+            (module->*method)(reactContext, GetOrCreateContextRuntime(reactContext, runtimeHandle));
         };
   }
 };