diff --git a/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs b/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
index 090842acf61827..b6d078641d2f7a 100644
--- a/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
+++ b/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
@@ -71,6 +71,8 @@ public static bool IsNonZeroLowerBoundArraySupported
         public static bool IsExceptionInteropSupported => IsWindows && !Utilities.IsNativeAot && !Utilities.IsMonoRuntime && !Utilities.IsCoreClrInterpreter;
 
         public static bool IsMonoRuntime => Type.GetType("Mono.RuntimeStructs") != null;
+        public static bool IsCoreCLR => !IsMonoRuntime && Utilities.IsNotNativeAot;
+        public static bool IsNotCoreCLR => !IsCoreCLR;
 
         static string _variant = Environment.GetEnvironmentVariable("DOTNET_RUNTIME_VARIANT");
 
diff --git a/src/tests/GC/Coverage/271010.cs b/src/tests/GC/Coverage/271010.cs
index cb89691f21d4fd..081887f2551460 100644
--- a/src/tests/GC/Coverage/271010.cs
+++ b/src/tests/GC/Coverage/271010.cs
@@ -12,7 +12,11 @@
 
 public class Test_271010 {
 
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/5933", TestRuntimes.CoreCLR)]
+    public static bool IsCoreClrOnNonBrowser =>
+        TestLibrary.PlatformDetection.IsCoreCLR &&
+        !TestLibrary.PlatformDetection.IsBrowser;
+
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/5933", typeof(Test_271010), nameof(IsCoreClrOnNonBrowser))]
     [Fact]
     public static int TestEntryPoint() {
 
diff --git a/src/tests/JIT/HardwareIntrinsics/General/HwiOp/HwiSideEffects.cs b/src/tests/JIT/HardwareIntrinsics/General/HwiOp/HwiSideEffects.cs
index 07552c31e572ac..7c89998df8a380 100644
--- a/src/tests/JIT/HardwareIntrinsics/General/HwiOp/HwiSideEffects.cs
+++ b/src/tests/JIT/HardwareIntrinsics/General/HwiOp/HwiSideEffects.cs
@@ -35,7 +35,7 @@ private static uint ProblemWithInterferenceChecks(uint a)
     }
 
     [Fact]
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/114250", TestPlatforms.Browser)]
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/114250", typeof(TestLibrary.PlatformDetection), nameof(TestLibrary.PlatformDetection.IsBrowser), nameof(TestLibrary.PlatformDetection.IsMonoRuntime))]
     public static void TestProblemWithThrowingLoads()
     {
         Assert.True(ProblemWithThrowingLoads(null));
diff --git a/src/tests/JIT/Methodical/eh/interactions/switchinfinally.cs b/src/tests/JIT/Methodical/eh/interactions/switchinfinally.cs
index 8d4878c219a646..acafd243cab9b1 100644
--- a/src/tests/JIT/Methodical/eh/interactions/switchinfinally.cs
+++ b/src/tests/JIT/Methodical/eh/interactions/switchinfinally.cs
@@ -87,7 +87,8 @@ static Class1()
         /// The main entry point for the application.
         /// </summary>
         [Fact]
-        [ActiveIssue("needs triage", TestPlatforms.Browser | TestPlatforms.Wasi | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+        [ActiveIssue("needs triage", TestPlatforms.Wasi | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+        [ActiveIssue("needs triage", typeof(TestLibrary.PlatformDetection), nameof(TestLibrary.PlatformDetection.IsBrowser), nameof(TestLibrary.PlatformDetection.IsMonoRuntime))]
         public static int TestEntryPoint()
         {
             //Start recording
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.cs b/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.cs
index ec4b9513161f8a..8446bc8f890572 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.cs
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.cs
@@ -6934,8 +6934,8 @@ static unsafe bool MemoryCompare(byte* left, byte* right, int byteCount)
             return true;
         }
 
-        [ActiveIssue("needs triage", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
-        [ActiveIssue("needs triage", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoInterpreter))]
+        [ActiveIssue("needs triage", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
+        [ActiveIssue("needs triage", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoInterpreter), nameof(PlatformDetection.IsMonoRuntime))]
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/91923", typeof(PlatformDetection), nameof(PlatformDetection.IsAppleMobile))]
         public static unsafe int TestEntryPoint()
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.tt b/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.tt
index 397c3e64d908c2..79d2e6ce4a5fb8 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.tt
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_64125/Runtime_64125.tt
@@ -12,6 +12,8 @@
 using System;
 using System.Runtime.CompilerServices;
 using System.Runtime.InteropServices;
+using TestLibrary;
+using Xunit;
 
 namespace Runtime_64125
 {
@@ -67,7 +69,7 @@ namespace Runtime_64125
 #>
     }
 
-    class Program
+    public class Program
     {
         static unsafe void Init(byte* bytes, int byteCount)
         {
@@ -87,7 +89,11 @@ namespace Runtime_64125
             return true;
         }
 
-        static unsafe int Main()
+        [ActiveIssue("needs triage", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
+        [ActiveIssue("needs triage", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoInterpreter), nameof(PlatformDetection.IsMonoRuntime))]
+        [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/91923", typeof(PlatformDetection), nameof(PlatformDetection.IsAppleMobile))]
+        public static unsafe int TestEntryPoint()
         {
             var anyLocation = new AnyLocation();
 
diff --git a/src/tests/JIT/SIMD/Matrix4x4.cs b/src/tests/JIT/SIMD/Matrix4x4.cs
index 898da73100fbd6..6634487539930f 100644
--- a/src/tests/JIT/SIMD/Matrix4x4.cs
+++ b/src/tests/JIT/SIMD/Matrix4x4.cs
@@ -9,6 +9,12 @@ public class Matrix4x4Test
     private const int Pass = 100;
     private const int Fail = -1;
 
+    public static bool IsInterpreterExceptCoreClrBrowser =>
+        TestLibrary.Utilities.IsCoreClrInterpreter &&
+        (!OperatingSystem.IsBrowser() ||
+         TestLibrary.Utilities.IsMonoRuntime ||
+         TestLibrary.Utilities.IsNativeAot);
+
     public static int Matrix4x4CreateScaleCenterTest3()
     {
         int returnVal = Pass;
@@ -31,7 +37,7 @@ public static int Matrix4x4CreateScaleCenterTest3()
         return returnVal;
     }
 
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/123104", typeof(TestLibrary.Utilities), nameof(TestLibrary.Utilities.IsCoreClrInterpreter))]
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/123104", typeof(Matrix4x4Test), nameof(IsInterpreterExceptCoreClrBrowser))]
     [Fact]
     public static int TestEntryPoint()
     {
diff --git a/src/tests/JIT/opt/Vectorization/StackallocBlkTests.cs b/src/tests/JIT/opt/Vectorization/StackallocBlkTests.cs
index 9003909b6f908a..4ba525db6ff2a2 100644
--- a/src/tests/JIT/opt/Vectorization/StackallocBlkTests.cs
+++ b/src/tests/JIT/opt/Vectorization/StackallocBlkTests.cs
@@ -11,7 +11,7 @@
 
 public unsafe class StackallocTests
 {
-    [ActiveIssue("https://github.com/dotnet/runtime/issues/84398", TestPlatforms.Windows, runtimes: TestRuntimes.Mono)]
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/84398", typeof(PlatformDetection), nameof(PlatformDetection.IsNotCoreCLR))]
     [Fact]
     public static int TestEntryPoint()
     {
diff --git a/src/tests/baseservices/invalid_operations/Arrays.cs b/src/tests/baseservices/invalid_operations/Arrays.cs
index 37cb37ff7cb6cd..b0e81945073cb6 100644
--- a/src/tests/baseservices/invalid_operations/Arrays.cs
+++ b/src/tests/baseservices/invalid_operations/Arrays.cs
@@ -12,7 +12,8 @@ public class Arrays
 {
     private class TestClass { }
 
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
     [Fact]
     public static void TypeMismatch_ArrayElement()
@@ -24,8 +25,9 @@ public static void TypeMismatch_ArrayElement()
         Assert.IsType<ArrayTypeMismatchException>(e.InnerException);
     }
 
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
     [Fact]
     public static void TypeMismatch_MultidimensionalArrayElement()
     {
@@ -36,8 +38,9 @@ public static void TypeMismatch_MultidimensionalArrayElement()
         Assert.IsType<ArrayTypeMismatchException>(e.InnerException);
     }
 
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
     [Fact]
     public static void TypeMismatch_ClassElement()
     {
diff --git a/src/tests/baseservices/invalid_operations/ManagedPointers.cs b/src/tests/baseservices/invalid_operations/ManagedPointers.cs
index 44f99b77d180b6..c6c20f344793f0 100644
--- a/src/tests/baseservices/invalid_operations/ManagedPointers.cs
+++ b/src/tests/baseservices/invalid_operations/ManagedPointers.cs
@@ -11,8 +11,9 @@
 
 public unsafe class ManagedPointers
 {
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
     [Fact]
     public static void Validate_BoxingHelpers_NullByRef()
     {
@@ -31,8 +32,9 @@ public static void Validate_BoxingHelpers_NullByRef()
         });
     }
 
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
     [Fact]
     [Xunit.SkipOnCoreClrAttribute("Depends on marshalled calli", RuntimeTestModes.InterpreterActive)]
     public static void Validate_GeneratedILStubs_NullByRef()
@@ -58,8 +60,9 @@ public static void Validate_GeneratedILStubs_NullByRef()
         static nint PassByRef(void* a) => (nint)a;
     }
 
+    [ActiveIssue("Function mismatch", TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
+    [ActiveIssue("Function mismatch", typeof(PlatformDetection), nameof(PlatformDetection.IsBrowser), nameof(PlatformDetection.IsMonoRuntime))]
     [ActiveIssue("Doesn't compile with LLVM AOT.", typeof(PlatformDetection), nameof(PlatformDetection.IsMonoAnyAOT))]
-    [ActiveIssue("Function mismatch", TestPlatforms.Browser | TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst)]
     [Fact]
     public static void Validate_IntrinsicMethodsWithByRef_NullByRef()
     {